2025 NFL Odds: Early Lines For Every Monday Night Matchup

The 2025-26 NFL season is just around the corner, with teams wrapping up minicamps and training camps set to begin soon.

And one of the most notable staples of every NFL season is, of course, Monday Night Football.

An NFC North rivalry game between the Minnesota Vikings and the Chicago Bears will kick off this year’s MNF schedule.

In Weeks 2, 4, 6 and 7, fans will see doubleheaders, while the Week 18 slot is on hold until the league decides which teams will be flexed. 

Who are the early favorites in each matchup? 

Can Caleb Williams turn the Bears around in Year 2?

Let’s check out the lines for each Monday Night Football game at DraftKings Sportsbook as of July 2.

(All times ET)

2025-26 Monday Night Football odds

WEEK 1, SEPT. 8 

Vikings @ Bears (8:15 p.m., ABC/ESPN)

Point spread: Bears -1.5 (Bears favored to win by more than 1.5 points, otherwise Vikings cover)
Moneyline: Bears -115 favorites to win; Vikings -105 underdogs to win
Total scoring Over/Under: 45.5 points scored by both teams combined

WEEK 2, SEPT. 15 

Buccaneers @ Texans (7 p.m., ABC/ESPN)

Point spread: Texans -1.5 (Texans favored to win by more than 1.5 points, otherwise Buccaneers cover)
Moneyline: Texans -120 favorites to win; Buccaneers +100 underdogs to win
Total scoring Over/Under: 46.5 points scored by both teams combined

WEEK 2, SEPT. 15 

Chargers @ Raiders (10 p.m., ESPN)

Point spread: Chargers -3 (Chargers favored to win by more than 3 points, otherwise Raiders cover)
Moneyline: Chargers -148 favorites to win; Raiders +124 underdogs to win
Total scoring Over/Under: 44.5 points scored by both teams combined

WEEK 3, SEPT. 22 

Lions @ Ravens (8:15 p.m., ABC/ESPN)

Point spread: Ravens -3.5 (Ravens favored to win by more than 3.5 points, otherwise Lions cover)
Moneyline: Ravens -175 favorites to win; Lions +145 underdogs to win
Total scoring Over/Under: 49.5 points scored by both teams combined

Will the Lions take a step back this season?

WEEK 4, SEPT. 29 

Jets @ Dolphins (7:15 p.m., ABC)

Point spread: Dolphins -5.5 (Dolphins favored to win by more than 5.5 points, otherwise Jets cover)
Moneyline: Dolphins -225 favorites to win; Jets +185 underdogs to win
Total scoring Over/Under: 44.5 points scored by both teams combined

WEEK 4, SEPT. 29 

Bengals @ Broncos (8:15 p.m., ESPN)

Point spread: Broncos -2.5 (Broncos favored to win by more than 2.5 points, otherwise Bengals cover)
Moneyline: Broncos -130 favorites to win; Bengals +110 underdogs to win
Total scoring Over/Under: 47.5 points scored by both teams combined

WEEK 5, OCT. 6 

Chiefs @ Jaguars (8:15 p.m., ABC/ESPN)

Point spread: Chiefs -4.5 (Chiefs favored to win by more than 4.5 points, otherwise Jaguars cover)
Moneyline: Chiefs -205 favorites to win; Jaguars +170 underdogs to win
Total scoring Over/Under: 47.5 points scored by both teams combined

Chiefs have third-best odds to win Super Bowl LX

WEEK 6, OCT. 13 

Bills @ Falcons (7:15 p.m., ESPN)

Point spread: Bills -5.5 (Bills favored to win by more than 5.5 points, otherwise Falcons cover)
Moneyline: Bills -218 favorites to win; Falcons +180 underdogs to win
Total scoring Over/Under: 48.5 points scored by both teams combined

WEEK 6, OCT. 13 

Bears @ Commanders (8:15 p.m., ABC)

Point spread: Commanders -4.5 (Commanders favored to win by more than 4.5 points, otherwise Bears cover)
Moneyline: Commanders -198 favorites to win; Bears +164 underdogs to win
Total scoring Over/Under: 48.5 points scored by both teams combined

WEEK 7, OCT. 20

Buccaneers @ Lions (7 p.m., ABC/ESPN)

Point spread: Lions -3.5 (Lions favored to win by more than 3.5 points, otherwise Buccaneers cover)
Moneyline: Lions -185 favorites to win; Buccaneers +154 underdogs to win
Total scoring Over/Under: 49.5 points scored by both teams combined

WEEK 7, OCT. 20 

Texans @ Seahawks (10 p.m., ESPN+)

Point spread: Seahawks -1.5 (Seahawks favored to win by more than 1.5 points, otherwise Texans cover)
Moneyline: Seahawks -120 favorites to win; Texans +100 underdogs to win
Total scoring Over/Under: 44.5 points scored by both teams combined

WEEK 8, OCT. 27 

Commanders @ Chiefs (8:15 p.m., ABC/ESPN)

Point spread: Chiefs -3.5 (Chiefs favored to win by more than 3.5 points, otherwise Commanders cover)
Moneyline: Chiefs -192 favorites to win; Commanders +160 underdogs to win
Total scoring Over/Under: 48.5 points scored by both teams combined

WEEK 9, NOV. 3 

Cardinals @ Cowboys (8:15 p.m., ABC/ESPN)

Point spread: Cowboys -1.5 (Cowboys favored to win by more than 1.5 points, otherwise Cardinals cover)
Moneyline: Cowboys -120 favorites to win; Cardinals +100 underdogs to win
Total scoring Over/Under: 47.5 points scored by both teams combined

Does paying Micah Parsons get the Cowboys closer to or further from a Super Bowl?

WEEK 10, NOV. 10

Eagles @ Packers (8:15 p.m., ABC/ESPN)

Point spread: Eagles -1.5 (Eagles favored to win by more than 1.5 points, otherwise Packers cover)
Moneyline: Eagles -122 favorites to win; Packers +102 underdogs to win
Total scoring Over/Under: 45.5 points scored by both teams combined

WEEK 11, NOV. 17 

Cowboys @ Raiders (8:15 p.m., ABC/ESPN)

Point spread: Cowboys -1.5 (Cowboys favored to win by more than 1.5 points, otherwise Raiders cover)
Moneyline: Cowboys -120 favorites to win; Raiders +100 underdogs to win
Total scoring Over/Under: 45.5 points scored by both teams combined

WEEK 12, NOV. 24

Panthers @ 49ers (8:15 p.m., ESPN)

Point spread: 49ers -7 (49ers favored to win by more than 7 points, otherwise Panthers cover)
Moneyline: 49ers -298 favorites to win; Panthers +240 underdogs to win
Total scoring Over/Under: 46.5 points scored by both teams combined

WEEK 13, DEC. 1

Giants @ Patriots (8:15 p.m., ESPN)

Point spread: Patriots -3 (Patriots favored to win by more than 3 points, otherwise Giants cover)
Moneyline: Patriots -155 favorites to win; Giants +130 underdogs to win
Total scoring Over/Under: 42.5 points scored by both teams combined

WEEK 14, DEC. 8

Eagles @ Chargers (8:15 p.m., ABC/ESPN)

Point spread: Eagles -2.5 (Eagles favored to win by more than 2.5 points, otherwise Chargers cover)
Moneyline: Eagles -130 favorites to win; Chargers +130 underdogs to win
Total scoring Over/Under: 45.5 points scored by both teams combined

Aaron Rodgers ‘pretty sure’ he’s retiring after this season — will he succeed with Steelers?

WEEK 15, DEC. 15

Dolphins @ Steelers (8:15 p.m., ESPN)

Point spread: Steelers -2.5 (Steelers favored to win by more than 2.5 points, otherwise Dolphins cover)
Moneyline: Steelers -135 favorites to win; Dolphins +114 underdogs to win
Total scoring Over/Under: 42.5 points scored by both teams combined

WEEK 16, DEC. 22

49ers @ Colts (8:15 p.m., ESPN)

Point spread: 49ers -3 (49ers favored to win by more than 3 points, otherwise Colts cover)
Moneyline: 49ers -162 favorites to win; Colts +136 underdogs to win
Total scoring Over/Under: 46.5 points scored by both teams combined

WEEK 17, DEC. 29

Rams @ Falcons (8:15 p.m., ESPN)

Point spread: Rams -3 (Rams favored to win by more than 3 points, otherwise Falcons cover)
Moneyline: Rams -162 favorites to win; Falcons +136 underdogs to win
Total scoring Over/Under: 46.5 points scored by both teams combined

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